Seth Rogen on Getting High with Paul McCartney, Sexy Scene with Penélope Cruz & First Colonoscopy

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Seth talks to Guest Host Ike Barinholtz about the first time they met, Ike embarrassing him when they were smoking pot with Paul McCartney at the SNL afterparty, shooting season two of The Studio, getting his first colonoscopy, his movie The Invite, filming sexy scenes with Penélope Cruz, and getting another Emmy nomination for The Muppet Show. SUBSCRIBE to get the latest #Kimmel: http://bit.ly/JKLSubscribe Follow Jimmy Kimmel on Instagram: https://bit.ly/KimmelInstagram Follow Jimmy Kimmel Live on Instagram: http://bit.ly/JKLInstagram Follow Jimmy Kimmel Live on TikTok: https://bit.ly/JKLTikTok Like Jimmy Kimmel on Facebook: http://bit.ly/KimmelFB Like Jimmy Kimmel Live on Facebook: http://bit.ly/JKLFacebook Visit the Jimmy Kimmel Live Website : http://bit.ly/JKLWebsite About Jimmy Kimmel Live: Jimmy Kimmel serves as host and executive producer of Emmy® nominated “Jimmy Kimmel Live,” ABC’s late-night talk show. “Jimmy Kimmel Live” is well known for its viral video successes, with over 16 billion views and more than 19 million subscribers on the show’s YouTube channel. Some of Kimmel’s most popular comedy bits include Celebrities Read Mean Tweets, Lie Witness News, Halloween Candy YouTube Challenge, Jimmy and Cousin Sal pranking Aunt Chippy and music stars like Rihanna and Dua Lipa surprising Jimmy in the middle of the night.