Why Depression Isn’t What We Think | Lisa Monteggia | TED

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The idea that depression comes from a chemical imbalance in the brain has shaped treatment for decades. Neuroscientist Lisa Monteggia shares research suggesting that's not the whole story — and shows how a decades-old drug could upend what we thought we knew about depression, with the potential to offer relief within hours. (Recorded at TEDxNashvilleWomen on August 21, 2025) Join us in person at a TED conference: https://tedtalks.social/events Become a TED Member to support our mission: https://ted.com/membership Subscribe to a TED newsletter: https://ted.com/newsletters Follow TED! Instagram: https://www.instagram.com/ted LinkedIn: https://www.linkedin.com/company/ted-conferences TikTok: https://www.tiktok.com/@tedtoks Facebook: https://facebook.com/TED X: https://www.twitter.com/TEDTalks The TED Talks channel features the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less) — plus originals, podcasts and exclusive content. Look for videos on Technology, Entertainment and Design as well as science, business, global issues, the arts and more. Visit https://TED.com for our entire library, transcripts, translations and personalized recommendations. Watch more: https://go.ted.com/lisamonteggia https://youtu.be/3Ae4qCvQIcM TED videos may be used for non-commercial purposes under a Creative Commons License, Attribution–Non Commercial–No Derivatives (or the CC BY – NC – ND 4.0 International) and in accordance with the TED Talks Usage Policy: https://www.ted.com/about/our-organization/our-policies-terms/ted-talks-usage-policy. For more information on using TED for commercial purposes (e.g. employee learning, in a film or online course), submit a request at https://media-requests.ted.com #TED #TEDTalks #Science #Depression