About this episode
<p><a href="https://twitter.com/LauraDeming">Laura Deming</a> is a partner at <a href="https://longevity.vc/">The Longevity Fund</a>. They invest in companies that will allow us to live longer and healthier lives.<br><br>You can learn more about them at <a href="https://longevity.vc/">Longevity.vc</a>.<br><br>Laura’s on Twitter <a href="https://twitter.com/LauraDeming">@LauraDeming</a>.<br><br>The YC podcast is hosted by <a href="https://twitter.com/craigcannon">Craig Cannon</a>.<br><br>***<br><br><b>Topics</b><br><br>00:22 - Why focus on longevity now?<br><br>2:12 - How did Laura get started in longevity?<br><br>3:22 - Why raise a fund?<br><br>5:52 - What does Laura do personally for longevity?<br><br>9:07 - Worm and mouse studies<br><br>10:44 - Craig's personal habits<br><br>12:37 - Human studies<br><br>15:22 - Mica asks - Do you think immortality is going to be achieved by: 1. Curing all disease and stop aging so we could live with our own bodies forever 2. OR is going to be something like porting our brain, "mind" to a computer/robot?<br><br>17:37 - Most likely strategies to increase lifespan<br><br>19:47 - Ryan Hoover asks - Ask about the ethics of longevity. Jack J. Fernandes asks - Do people actually want to live longer?<br><br>21:44 - Mica asks - How would immortality change society? Wouldn't we become more complacent? Since we have "forever" to do things wouldn't that diminish our rate of innovation? And since less new individuals are being created we would have access to less new ideas. We would just stop creating new Newtons, Einsteins, Mozarts…<br><br>24:52 - Cognitive enhancement<br><br>25:52 - Daily habits<br><br>34:12 - Tech environment changes in the past 5-10 years<br><br>39:22 - What percentage of people in labs want to start companies?<br><br>41:37 - Pioneer<br><br>43:57 - Confidence<br><br>45:52 - Podcasting<br><br>49:12 - Choosing media to consume<br><br>52:17 - Sam Betesh asks - The last thing that led to a step function change in average life span was germ theory. What new areas of research might provide the next step function change?<br><br>55:07 - Extending fertility windows<br><br>57:22 - Jason Choi asks - What % of longevity is attributable to lifestyle choices vs genetics and the progress of technology in influencing both.<br><br>58:37 - Fatih asks - is blood transfusion a thing or just a hoax<br><br>1:00:42 - Rapamycin<br><br>1:02:27 - Testosterone<br><br>1:04:37 - Chris asks - Aubrey De Grey, IIRC, mentioned a number of times that we might, in the future, replace organs and tissues with new organic ones before they fail. Is this actually a reasonable idea, or is it more likely that we'll replace them with synthetic ones, if we replace them at all?<br><br>1:06:07 - Mica asks - Laura did a "cookie diet" for one month. Why did you do it? How did you feel? Doesn't it go against all the research on longevity? ;-)<br><br>1:08:07 - Is Laura actually not doing anything strange in her diet?<br></p>
Listen to this episode in English to learn English
Podcast episodes are one of the highest-density ways to absorb English at native pace. #99 - Laura Deming from Y Combinator Startup Podcast gives you natural dialogue, unscripted speech, and vocabulary that actually appears in real conversations.
In the Hinto app, every word in the transcript is tappable. Tap an unknown word, see the translation in your language instantly, and keep listening without breaking flow.
Episodes to Learn English
- 8 Ways To Improve Your Outbound Sales Sep 13, 2026
- Open Models Change The Economics of AI Sep 12, 2026
- Paul Graham On Startups, Ambition, and Great Founders Sep 5, 2026
- The World’s Largest Electric Aircraft Just Flew Sep 4, 2026
- Max Junestrand: You Need The Willingness To Learn Faster Than Anyone Else Aug 29, 2026
- Susan Kare: Designing Icons & Graphics For the Original Mac Aug 28, 2026
- Chelsea Finn: This is the State of the Art in Robotics Aug 13, 2026
- Peter Steinberger: "Fun Is Velocity" Aug 11, 2026
- Max Hodak: How Startups Build Speed Aug 10, 2026
- How To Design In The Agent Era Aug 7, 2026
- Garry Tan: Own Your Intelligence Aug 6, 2026
- Building the First Data Centers in Space Aug 5, 2026
- Waymo Co-CEO Dmitri Dolgov: "Move Fast And Ship Safely" Aug 4, 2026
- Patrick Collison: "What If You Succeed?" Aug 3, 2026
- Jeff Dean: The 1% Rule for Building in AI Aug 1, 2026
- Alexandr Wang: “This is a Once-in-a-Civilization Opportunity” Jul 31, 2026
- Blake Scholl: Breaking the Supersonic Ban Jul 29, 2026
- Sam Altman: "Never a Better Time to Do a Startup" Jul 28, 2026
- Boris Cherny: Building Claude Code Jul 28, 2026
- Jensen Huang: The Mindset That Built NVIDIA Jul 27, 2026
- World Models, Explained Jul 17, 2026
- How To Better Understand Your Users Jul 9, 2026
- Why Domain Experts Are Winning In The Age Of AI Jun 19, 2026
- How To Pick A Startup Idea Jun 17, 2026
- "The CEO Must Be the Chief AI Officer" Jun 10, 2026
- How to Build an AI-Native Services Company Jun 3, 2026
- How To Build Superintelligence Inside Your Company May 27, 2026
- How The Best Companies Defend Against Mediocrity And Rot May 25, 2026
- Paul Graham: Should you move to Silicon Valley? May 13, 2026
- Tokenmaxxing: How Top Builders Use AI To Do The Work Of 400 Engineers May 8, 2026